CREATINE AS AN ANTIOXIDANT TO ATTENUATE KIDNEY DAMAGE CAUSED BY DOXORUBICIN

ABSTRACT

Doxorubicin (DOX) is a common chemotherapy drug that while effective can weaken a patient immensely. A reaction of DOX is the increased creation of free radical species that can be damaging to cellular tissue. With this higher number of free radicals there is a lower antioxidants or free radical scavengers that can counter the damage, this imbalance is called oxidative stress. The kidney is one organ that is very vulnerable to oxidative stress. A treatment has yet to studied to counteract this side effect of DOX. Within this research, is to see if creatine (Cr) with antioxidant properties can attenuate the oxidative stress caused by DOX within the kidneys of twenty-eight Sprague-Dawley rats. Splitting the rats into four groups, Control plus saline (C + Sal, n=7), control DOX (C + DOX, n=7), creatine saline (Cr + Sal, n=7), and creatine DOX (Cr + DOX, n=7).