Literature Review

Creatine has been a possible positive antioxidant against reactive oxygen spices.  The article (Riesberg, Weed, McDonald, Eckerson, & Drescher, 2016) discuss the role of creatine in the human bodies and how it’s been used in history. It covers how current creatine supplement, creatine monohydrate, has a low bioavailability, or an active effect on the body. Then covers how creatine should have farther studies on neurological disease, such as in the article, traumatic brain injury, Huntington's disease, Parkinson's disease, and more. The authors also presented a case for creatine as an anti-inflammatory agent. There is also a section on creatine having antioxidant properties that helps understand my research. The article (Sestili, et al., 2011) goes into proof that creatine has antioxidant properties. The authors explain how creatine has many beneficial factors including as an antioxidant. Within the article it supports that test against the hypothesis, of being a possible antioxidant, proved that creatine could act as a radical scavenger. It suggests that the antioxidant ability is from less muscle fatigue, such as in athletes using creatine supplements. The author Sestili went testing for antioxidant properties of creatine and found that oxidative stressors causing cytotoxicity, with creatine preloading, found that the creatine was able to be cytoprotective. The article also goes on to summarize its findings, stating that creatine can protect RNA and DNA from oxidative stress on an array of reactive oxygen species.